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High clearance continuous renal replacement therapy with a modified dialysis machine.
C Schlaeper1, R Amerling, M Manns
1Fresenius Medical Care, Lexington, Massachusetts 02420, USA. christian.schlaeper@fmc-na.com
Kidney International. Supplement
|November 24, 1999
Summary
Slow continuous dialysis (SCD) offers a safe and effective treatment for acute renal failure (ARF). This method utilizes specific blood and dialysate flow rates with bicarbonate dialysate for improved patient outcomes.
Area of Science:
- Nephrology
- Critical Care Medicine
Background:
- Dialysis dose impacts survival in acute renal failure (ARF) patients.
- Bicarbonate dialysate enhances acid-base balance during continuous renal replacement therapy (CRRT).
Purpose of the Study:
- To investigate the efficacy and safety of slow continuous dialysis (SCD) for treating ARF.
- To leverage findings on dialysis dose and bicarbonate dialysate in a novel treatment approach.
Main Methods:
- SCD parameters: blood flow (Q(B)) 100-200 ml/min, dialysate flow (Q(D)) 100-300 ml/min.
- Utilized a modified hemodialysis machine with controlled ultrafiltration and online bicarbonate dialysate production.
- Treatment administered continuously or extended daily for 8-24 hours.
Main Results:
- SCD achieved urea clearance rates between 70-80 ml/min.
- Preliminary data from an ongoing clinical trial indicate safety and efficiency.
- The treatment demonstrated simplicity in application.
Conclusions:
- Slow continuous dialysis (SCD) is a safe and efficient method for ARF treatment.
- The technique offers a promising approach for managing acid-base balance and solute removal in ARF patients.
- Further clinical data will solidify SCD's role in critical care nephrology.