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Published on: August 8, 2013
Cardiac troponin T levels in umbilical cord blood
S D Shelton1, B L Fouse, C M Holleman
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Objective:
We sought to determine cardiac troponin T concentrations in umbilical cord plasma from normal and complicated pregnancies.
Study Design:
At the time of delivery, umbilical cord arterial and venous samples were collected from 209 neonates, and cardiac troponin T levels were measured by immunoassay. Comparisons of clinical factors were made between neonates with normal and elevated cardiac troponin T levels. Significance was deemed present at P <.05.
Results:
Twelve neonates had elevated cardiac troponin T levels. Exposure to magnesium sulfate was associated with an elevated cardiac troponin T level (relative risk, 33.2; 95% confidence interval, 7.7-143).
Conclusions:
Cardiac troponin T levels were elevated in neonates exposed to magnesium sulfate in utero. The explanation of this finding and its clinical significance are unknown. Characterization of fetal and neonatal troponin T requires further study.
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