Related Experiment Video

Updated: May 5, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
06:32

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

7.7K

Decreased no-reflow in patients with anterior myocardial infarction and pre-infarction angina

D Karila-Cohen1, D Czitrom, E Brochet

  • 1Service de Cardiologie, Hôpital Bichat, Paris, France.

European Heart Journal
|November 24, 1999
PubMed

Insights

Pre-infarction angina reduces no-reflow after myocardial infarction by preserving microvasculature. This finding suggests a mechanism for improved left ventricular function recovery in patients experiencing angina before a heart attack.

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Myocardial Infarction

Background:

  • Pre-infarction angina is linked to improved outcomes post-myocardial infarction.
  • The impact of pre-infarction angina on microvascular reperfusion after coronary recanalization remains unclear.

Purpose of the Study:

  • To investigate the association between pre-infarction angina and the incidence of no-reflow following coronary recanalization in patients with acute myocardial infarction.
  • To evaluate the effect of pre-infarction angina on myocardial perfusion and subsequent left ventricular function recovery.

Main Methods:

  • Intracoronary myocardial contrast echocardiography was used to assess myocardial perfusion in the area at risk after successful coronary recanalization.
  • Left ventricular function was evaluated using radionuclide angiography and 2D echocardiography at various time points post-myocardial infarction.
  • Patients were categorized into two groups: those with pre-infarction angina (angina within 7 days before MI) and those without.

Main Results:

  • Patients with pre-infarction angina exhibited significantly higher myocardial contrast echocardiography perfusion scores in the area at risk compared to those without.
  • The incidence of no-reflow was substantially lower in patients with pre-infarction angina (14%) versus those without (56%).
  • Pre-infarction angina was associated with greater mid-term improvement in left ventricular ejection fraction and regional wall motion recovery.

Conclusions:

  • Pre-infarction angina is associated with preserved microvasculature and reduced no-reflow after myocardial infarction.
  • The protective effect on microvasculature may explain the enhanced recovery of left ventricular function observed in patients with pre-infarction angina.
Abstract

More Related Videos

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

11.1K
Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice05:07

Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice

Published on: August 25, 2023

2.2K

Related Concept Videos

Antianginal Drugs: Nitrates and β-Blockers01:16

Antianginal Drugs: Nitrates and β-Blockers

In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
1.9K
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
525
Angina II: Classification01:27

Angina II: Classification

Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
714
Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
484
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
495
Angina V: Nursing Management01:20

Angina V: Nursing Management

Angina, a symptom of myocardial ischemia, requires a structured nursing management approach to ensure effective care and prevent complications like myocardial infarction. Comprehensive nursing care involves assessing, diagnosing, planning, implementing interventions, and evaluating outcomes, all tailored to the individual patient's needs.Patient AssessmentNursing assessment begins with a detailed subjective evaluation of symptoms, which typically include chest pain or pressure radiating to the...
567