Does beta(3)-adrenoreceptor blockade attenuate acute exercise-induced reductions in leptin mRNA?

¹Exercise and Nutrition Program, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)

|November 24, 1999

Summary

Acute exercise reduces leptin mRNA in rat retroperitoneal fat via beta(3)-receptor stimulation. This mechanism explains how exercise impacts adipose tissue gene expression, despite increased serum leptin levels.

Area of Science:

Physiology
Endocrinology
Molecular Biology

Background:

Leptin, a key hormone in energy balance, is produced by adipose tissue.
The impact of acute exercise on leptin gene expression (mRNA) in specific fat depots remains incompletely understood.

Purpose of the Study:

To investigate the effect of acute exercise on leptin mRNA levels in rat white adipose tissue.
To determine the role of beta(3)-adrenergic-receptor stimulation in exercise-induced changes in leptin mRNA.

Main Methods:

Male Sprague-Dawley rats underwent acute exercise to exhaustion or served as controls.
Leptin mRNA levels in retroperitoneal and epididymal fat were measured.
A second experiment utilized a selective beta(3)-adrenergic-receptor antagonist (SR-59230A) to assess its role in exercise-induced leptin mRNA changes.

Main Results:

Acute exercise significantly reduced leptin mRNA in retroperitoneal fat but not epididymal fat.
Beta(3)-adrenergic-receptor antagonism blocked the exercise-induced downregulation of leptin mRNA in retroperitoneal fat.
Serum leptin levels unexpectedly increased following exercise, suggesting preformed leptin release.

Conclusions:

Beta(3)-adrenergic-receptor stimulation is a key mechanism mediating the acute exercise-induced downregulation of leptin mRNA in rat retroperitoneal adipose tissue.
Exercise influences adipose tissue leptin regulation through both transcriptional and post-transcriptional mechanisms.

Related Experiment Videos

Does beta(3)-adrenoreceptor blockade attenuate acute exercise-induced reductions in leptin mRNA?

Related Concept Videos

The sweating response of elite professional soccer players to training in the heat.

Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration.

Prediction of energy expenditure in a whole body indirect calorimeter at both low and high levels of physical activity.

Short-term dietary energy restriction reduces lean body mass but not performance in physically active men and women.

Intravenous glutamine does not stimulate mixed muscle protein synthesis in healthy young men and women.

Concurrent physical activity increases fat oxidation during the shift to a high-fat diet.

Advanced footwear technology improves sprinting mechanics and performance.

Female-Specific Echocardiography-Derived Cardiac Responses To The Cold Pressor Test.

Reliability and validity of surface electromyography for identifying contractile muscle fatigue during cycling in people with COPD.

Natural experiments in marathon running.

The impact of acute sleep fragmentation on muscle blood flow responses to handgrip exercise.

Cardiovascular and cognitive consequences of steep head-down tilt in awake older men.

Injury prevention and athlete health-risk management in freestyle wrestling: a scoping review of direct and transferable evidence.

Sex Differences in Peripheral Arterial Disease: Presentation, Treatment, and Outcomes.

Temporal trends in sports and exercise participation: a study in a population-representative sample of 96 948 European Union adults.

Nutrition prescription for climbing athletes on rock or artificial surfaces: are we guessing?

Reference Intervals and Prediction Equation for Sustained Maximal Inspiratory Pressure in Healthy Adults.

Feasibility of fNIRS for assessing n-back task-related prefrontal cortex oxygenation after continuous cycling at varying intensities: an evaluation of protocol feasibility.

Related Experiment Videos

Does beta(3)-adrenoreceptor blockade attenuate acute exercise-induced reductions in leptin mRNA?

Area of Science:

Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions:

Related Concept Videos

Related Articles