Related Experiment Videos
[Update on the pharmacological interactions of systemic antifungal agents]
1Servicio de Microbiología, Hospital Universitario La Fe, Avda. Campanar 21, 46009 Valencia.
Abstract:
The incidence of systemic fungal infections has increased considerably in the last few decades, however the number of available antifungal agents continues to be reduced. Furthermore, these infections tend to affect patients with severe underlying diseases who are treated with different types of medication which may interact with antifungal agents, thus reducing their therapeutic efficacy or increasing their toxicity. In this paper, we discuss the interactions of systemic antifungal agents with other medications and comment on their clinical consequences and the therapeutic approach to adopt in each case.
Insights
Systemic fungal infections are rising, but antifungal drug options are limited. This review examines how antifungal medications interact with other drugs, impacting treatment effectiveness and safety.
Area of Science:
- Mycology
- Pharmacology
- Infectious Diseases
Context:
- Rising incidence of systemic fungal infections globally.
- Limited development of new antifungal agents.
- Vulnerable patient populations with comorbidities often require polypharmacy.
Purpose:
- To review drug interactions involving systemic antifungal agents.
- To discuss the clinical consequences of these interactions.
- To provide guidance on therapeutic management.
Summary:
- Systemic antifungal medications can interact with various co-administered drugs.
- These interactions may lead to reduced antifungal efficacy or increased toxicity.
- Understanding and managing these interactions is crucial for patient outcomes.
Impact:
- Informs clinical practice regarding safe and effective antifungal therapy.
- Highlights the need for careful medication review in patients with fungal infections.
- Contributes to managing polypharmacy in immunocompromised individuals.