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Creatine kinase MB isoenzyme of noncardiac origin in elderly patients
P Alterman1, C Vigder, J Feldman
1Geriatric Department, Meir General Hospital, Kfar Saba, Israel.
Insights
Elevated creatine kinase MB (CKMB) levels may not always indicate heart attack in older adults. This study highlights that other factors can increase CKMB, urging caution when diagnosing cardiac injury in the elderly.
Area of Science:
- Biochemistry
- Cardiology
- Geriatrics
Background:
- Creatine kinase MB (CKMB) isoenzyme activity is a key diagnostic marker for acute myocardial infarction.
- Accurate diagnosis of cardiac injury is crucial, especially in vulnerable elderly populations.
Abstract:
Increased activity of creatine kinase MB (CKMB) isoenzyme is regarded as highly diagnostic for acute myocardial infarction. We report two cases of elderly patients with increased levels of CKMB but no evidence of cardiac injury. We conclude that numerous factors influence CKMB activity and that the suitability of this test for the diagnosis of cardiac muscle damage in the elderly should be viewed with caution.