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Lack of correlation between surface and interfacial activities of saponins and their hemolytic properties
S Steurer1, M Wurglics, W Likussar
1Institute of Pharmaceutical Chemistry, University of Graz, Austria.
Die Pharmazie
|November 24, 1999
Abstract:
For a series of model compounds (digitonin, aescine, tomatine, stevioside and ginsenoside Rg1) it was demonstrated that neither the surface nor the interfacial tension (n-decane/water) lowering properties of saponins can be correlated with their ability to induce hemolysis. Furthermore, no correlation was observed between the surface and interfacial activities of saponins and their hemolytic properties.