Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antimicrobial activity of selected cyclic dipeptides.

M Graz1, A Hunt, H Jamie

  • 1Cyclic Peptide Research Unit, University of Port Elizabeth, South Africa. bcacjg@upe.ac.za

Die Pharmazie
|November 24, 1999
PubMed
Summary

Cyclic dipeptides demonstrate broad-spectrum antimicrobial and antifungal properties. These compounds also enhance gastrointestinal cell maturation, suggesting potential pharmaceutical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The only Special Interest Group with a Stack - Evolution, Psychiatry and the Substack Platform.

Irish journal of psychological medicine·2024
Same author

Tranexamic acid in sinus and nasal surgery: an up-to-date meta-analysis.

The Journal of laryngology and otology·2021
Same author

A change in clinical practice for aural foreign bodies - what we learnt from the coronavirus disease 2019 pandemic.

The Journal of laryngology and otology·2021
Same author

High Performance Bi-2212 Round Wires Made with Recent Powders.

IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee·2021
Same author

Feasibility of magnetic resonance guided radiotherapy for the treatment of bladder cancer.

Clinical and translational radiation oncology·2020
Same author

Magnetic resonance imaging sequence evaluation of an MR Linac system; early clinical experience.

Technical innovations & patient support in radiation oncology·2020

Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Microbiology

Background:

  • Cyclic dipeptides are rationally designed molecules with potential antimicrobial and antitumor activities.
  • Investigating their effects on the gastrointestinal epithelium is crucial for pharmaceutical development.

Purpose of the Study:

  • To evaluate the antimicrobial and antifungal effects of specific cyclic dipeptides.
  • To assess the impact of these cyclic dipeptides on gastrointestinal epithelial cells in vitro.
  • To identify suitable solvents for potential pharmaceutical applications.

Main Methods:

  • Antimicrobial activity was determined using the Kirby-Bauer disc diffusion assay against a panel of bacteria and fungi.
  • Effects on gastrointestinal epithelium were assessed by measuring alkaline phosphatase expression in HT-29 cells.

Related Experiment Videos

  • Solvent screening was performed for pharmaceutical application suitability.

    • Main Results:

    • Cyclo(Pro-Trp) and cyclo(Phe-Pro) exhibited broad-spectrum antibacterial activity.
    • Cyclo(Trp-Pro) and cyclo(Trp-Trp) demonstrated broad-spectrum antifungal activity.
    • Cyclo(Phe-Pro), cyclo(Tyr-Pro), cyclo(Trp-Trp), and cyclo(Trp-Pro) enhanced gastrointestinal cell maturation.

    Conclusions:

    • The studied cyclic dipeptides possess significant antimicrobial and antifungal properties.
    • These compounds positively influence gastrointestinal cell maturation.
    • The findings support the potential of these cyclic dipeptides as pharmacological agents.