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Related Experiment Videos

Outer root sheath acanthoma.

M Reichel1, E R Heilman

  • 1Department of Dermatology, College of Physicians & Surgeons, Columbia University, New York, New York 10032, USA.

Journal of Cutaneous Pathology
|November 24, 1999
PubMed
Summary
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Outer root sheath acanthoma is a novel keratosis demonstrating differentiation of the entire outer root sheath. This unique lesion exhibits characteristics of all four tricholemmal differentiation types.

Area of Science:

  • Dermatopathology
  • Histopathology
  • Neoplastic Dermatology

Background:

  • The outer root sheath (ORS) is a complex follicular structure.
  • Understanding ORS differentiation is crucial for diagnosing follicular neoplasms.
  • Previous classifications have not fully encompassed ORS differentiation.

Observation:

  • A distinctive keratotic lesion was observed.
  • The lesion featured anastomosing keratinocyte columns originating from the epidermis.
  • These columns showed progressive ORS differentiation with depth.

Findings:

  • The lesion demonstrated differentiation characteristic of the infundibulum, isthmus, stem, and anagen bulb.
  • This represents differentiation of all four segments of the ORS.

Related Experiment Videos

  • The term "outer root sheath acanthoma" is proposed for this distinct entity.

    • Implications:

    • Outer root sheath acanthoma represents a true neoplasm of the entire ORS.
    • This finding expands the spectrum of follicular neoplasms.
    • Accurate classification aids in understanding and managing these unique lesions.