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Total neuropathy score: validation and reliability study.

D R Cornblath1, V Chaudhry, K Carter

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Neurology
|November 24, 1999
PubMed
Summary
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The Total Neuropathy Score (TNS) demonstrates excellent reliability and validity for assessing peripheral nerve function in both healthy individuals and those with diabetic polyneuropathy. This score is suitable for clinical trials.

Area of Science:

  • Neurology
  • Clinical Trials
  • Outcome Measurement

Background:

  • Validated outcome measures are crucial for peripheral neuropathy research.
  • The Total Neuropathy Score (TNS) integrates symptom grading, clinical signs, nerve conduction studies, and quantitative sensory tests into a single neuropathy quantification measure.
  • Previous studies utilized TNS in toxic neuropathy research.

Purpose of the Study:

  • To establish the validity and reliability of the Total Neuropathy Score (TNS).
  • To assess TNS performance in normal subjects and patients with diabetic polyneuropathy.

Main Methods:

  • Assessed inter- and intrarater reliability of the TNS.
  • Conducted a cross-sectional validation study comparing TNS with Mayo Clinic measures, Neuropathy Symptom Score (NSS), and Neurologic Impairment Score (NIS).

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  • Included five healthy controls and 30 individuals with diabetic polyneuropathy.

    • Main Results:

    • Excellent interrater (0.966) and intrarater (0.986) reliability for TNS.
    • Cross-sectional validation showed excellent correlations between TNS and other neuropathy measures.

    Conclusions:

    • The Total Neuropathy Score (TNS) is a validated tool for peripheral nerve function assessment.
    • TNS is a suitable endpoint for clinical trials investigating peripheral neuropathy.