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Food hypersensitivity in children.

J A Vanderhoof1

  • 1University of Nebraska/Creighton University, Omaha, USA.

Current Opinion in Clinical Nutrition and Metabolic Care
|November 24, 1999
PubMed
Summary
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Adverse food reactions affect 2-7% of North Americans, with non-IgE-mediated hypersensitivity being chronic and difficult to diagnose. Eliminating the allergen is key, and most infants outgrow formula protein intolerance by age three.

Area of Science:

  • Immunology
  • Pediatrics
  • Gastroenterology

Background:

  • Adverse food reactions impact 2-7% of North Americans, particularly children.
  • Reactions include both IgE-mediated and non-IgE-mediated responses.
  • Non-IgE-mediated food hypersensitivity presents chronically, often in infants, with symptoms like vomiting and diarrhea.

Purpose of the Study:

  • To review the presentation and diagnosis of non-IgE-mediated food hypersensitivity.
  • To highlight diagnostic challenges and management strategies for food allergies.

Main Methods:

  • Clinical presentation review.
  • Diagnostic challenges in non-IgE-mediated food hypersensitivity.
  • Dietary elimination as a primary management strategy.

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Main Results:

  • Non-IgE-mediated food hypersensitivity is challenging to diagnose, with skin tests and immunological studies being unhelpful.
  • A detailed patient history and physical examination are crucial for diagnosis.
  • Dietary elimination of the food allergen is the primary treatment.
  • Approximately 85% of infants with formula protein intolerance outgrow symptoms by age three.

Conclusions:

  • Non-IgE-mediated food hypersensitivity requires careful clinical evaluation.
  • Dietary management is essential for food allergies.
  • Prognosis for infants with formula protein intolerance is generally good, with most outgrowing the condition.