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Eosinophilic cellulitis (Well's syndrome): a new case description.
Journal of the European Academy of Dermatology and Venereology : JEADV
|November 24, 1999
Summary
Eosinophilic cellulitis, also known as Wells syndrome, presents as skin lesions that respond well to topical corticosteroids. This condition, characterized by eosinophils, can effectively be managed with targeted treatment, as demonstrated in a recent case study.
Area of Science:
- Dermatology
- Pathology
Background:
- Wells syndrome, or eosinophilic cellulitis, is a rare skin condition characterized by recurrent granulomatous dermatitis with eosinophilia.
- Key diagnostic criteria include sudden onset of specific skin lesions, characteristic histological findings ('flame figures'), and variable blood hypereosinophilia.
Observation:
- A 49-year-old woman presented with sudden onset of itchy, erythematous-edematous patches on her arms.
- These lesions evolved into hard, reddish-violet plaques.
- The patient had a history of breast cancer treatment, including surgery and cobalt therapy.
Findings:
- Histopathological examination confirmed eosinophilic cellulitis.
- Routine blood tests, autoantibody assays, and tumor marker tests were normal.
- Drug intake was ruled out as a cause.
Implications:
- Topical corticosteroid therapy provided rapid healing of the eosinophilic cellulitis lesions.
- The condition showed a tendency to relapse but responded consistently to the same topical treatment.
- A 1-year follow-up indicated sustained remission after treatment.