Comparison of tissue response between a synthetic gutta-percha and a natural gutta-percha endodontic filler

Biologic acceptance is one of several criteria that must be met by an endodontic filling material. The purpose fo this experiment was to compare a new filling material consisting of a synthetic gutta-percha with a standard material consisting of natural gutta-percha. Each sample, being an endodontic point, contained a quantity of fillers. The materials were implanted subcutaneously in male white rats. The histologic appearance was essentially identical for both materials.