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Related Experiment Videos

Inhaled antimicrobial therapy.

T O'Riordan1, M Faris

  • 1Division of Pulmonary and Critical Care Medicine, State University of New York at Stony Brook, 11794-8172, USA.

Respiratory Care Clinics of North America
|November 24, 1999
PubMed
Summary

Inhaled antimicrobial therapy, while controversial, shows promise in specific conditions like cystic fibrosis. Tobramycin inhalation may improve lung function and reduce bacterial load in these patients.

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Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Inhaled antimicrobial therapy has a long history but remains controversial with limited accepted indications.
  • The efficacy and clinical significance of inhaled antibiotics require further investigation across various respiratory conditions.

Purpose of the Study:

  • To review the current status and evidence for inhaled antimicrobial therapies.
  • To highlight established and emerging applications of inhaled antibiotics, antifungals, and antivirals.

Main Methods:

  • Review of existing literature on inhaled antimicrobial agents.
  • Analysis of clinical trial data for specific conditions such as cystic fibrosis and ventilator-associated tracheobronchitis.
  • Examination of prophylactic and therapeutic uses of inhaled medications.

Main Results:

  • Cyclical inhaled tobramycin in cystic fibrosis demonstrates benefits in reducing sputum, bacterial counts, and improving pulmonary function.
  • Preliminary data suggest inhaled antibiotics may reduce sputum volume in ventilator-associated tracheobronchitis, but clinical significance is undetermined.
  • Inhaled pentamidine is an option for Pneumocystis pneumonia prophylaxis in HIV patients intolerant to oral agents; inhaled ribavirin is used for respiratory syncytial virus.

Conclusions:

  • Inhaled tobramycin is a valuable treatment for cystic fibrosis patients.
  • Further research is needed to establish the role of inhaled antibiotics in ventilator-associated tracheobronchitis.
  • The utility of inhaled antifungal therapy, such as amphotericin B, remains to be determined.

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