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Allergic Reactions

Allergic Reactions

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Related Experiment Video

Updated: Jul 22, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Atopic eczema and the allergist.

E N Charlesworth¹

¹Department of Allergy, University of Texas School of Medicine at Houston, USA.

Allergy and Asthma Proceedings

|November 24, 1999

Summary

The skin is a dynamic immune organ, not just a barrier. It integrates with other immune cells and organs, highlighting its complex role in immunity and allergic skin diseases like atopic dermatitis.

Area of Science:

Immunology
Dermatology
Cell Biology

Background:

Historically viewed as a passive barrier, the skin is now recognized as a complex immune organ.
The skin is intricately connected with systemic immune functions involving bone marrow, lymph nodes, liver, and spleen.

Purpose of the Study:

To review the immunological functions of the skin.
To discuss the clinical complexities of atopic dermatitis as a model for allergic skin diseases.

Main Methods:

Review of current understanding of skin immunology.
Examination of the role of lymphocytes and Langerhans cells in skin immunity.
Clinical case review of atopic dermatitis.

Main Results:

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Last Updated: Jul 22, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

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Published on: September 26, 2019

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

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Lymphocytes express cutaneous lymphocyte-associated antigen (CLA), mediating skin homing.

Langerhans cells in the skin process antigens and interact with lymphocytes in lymph nodes.

The skin functions as a dynamic immune organ integrated with other immune system components.

Conclusions:

The skin is a highly active immune organ with extensive communication pathways.
Understanding skin immunity is crucial for managing allergic skin diseases such as atopic dermatitis.