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Updated: Sep 30, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Sepsis syndrome and bone marrow granulomatosis after intravesical instillation of BCG]
E Andrès1, C Kuhnert, A E Perrin
1Services de Médecine Interne et Nutrition, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre.
Background:
BCG therapy is an effective treatment for superficial bladder carcinoma. Exceptionally, systemic disorders including hypersensitivity reactions or infections may occur.
Case Report:
A 70-year-old man developed septicemia with bone marrow granulomatosis with a favorable course after intravesicle administration of bacillus Calmette-Guérin for bladder carcinoma.
Discussion:
High grade fever, septicemia, hepatitis or pulmonary granulomatosis as well as bone marrow involvement are reported in less than 1% of all cases of BCG therapy. The pathogenic mechanisms are complex. Anti-tuberculous drugs are generally given.
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