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Cerebral venous sinus thrombosis associated with hepatic cirrhosis

A B Singhal1, F Buonanno, G Rordorf

  • 1VBK 802, Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. asinghal@partners.org

Journal of the Neurological Sciences
|November 24, 1999
PubMed

Insights

Cerebral venous sinus thrombosis is a rare complication in end-stage liver disease. A case study highlights a patient with cirrhosis who developed sagittal sinus thrombosis, successfully treated with anticoagulation and liver transplant.

Area of Science:

  • Hepatology and Neurology
  • Thrombosis and Coagulation Disorders

Background:

  • End-stage liver disease (ESLD) is associated with complex coagulopathies.
  • Cerebral venous sinus thrombosis (CVST) is an uncommon neurological complication.

Observation:

  • A 44-year-old male with end-stage hepatic cirrhosis presented with recurrent seizures.
  • Imaging revealed sagittal sinus thrombosis as the sole manifestation.

Findings:

  • Severe deficiencies in protein C, protein S, and antithrombin III were identified.
  • Treatment with low molecular weight heparin and subsequent orthotopic liver transplant led to thrombosis resolution.

Implications:

  • This case suggests CVST may occur in ESLD, potentially linked to inherited thrombophilias.
  • Early diagnosis and management, including anticoagulation and liver transplantation, are crucial for favorable outcomes.

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