Related Experiment Videos
Corneal endothelial changes and aqueous flare intensity in pseudoexfoliation syndrome
L Wang1, R Yamasita, S Hommura
1Department of Ophthalmology, Doctoral Program in Medical Sciences, University of Tsukuba, Japan. md955401@igaku.md.tsukuba.ac.jp
Purpose:
To determine the changes of corneal endothelium in pseudoexfoliation (PEX) syndrome and the relations between their changes and aqueous flare intensity.
Methods:
26 eyes with PEX syndrome, 17 clinically unaffected fellow eyes and 27 normal age-matched eyes were studied. The corneal endothelium of the eyes was examined using a specular microscope, and the aqueous flare intensity of the eyes was measured using a laser flare cell meter.
Results:
The corneal endothelial density significantly decreased both in the eyes with PEX and in the clinically unaffected fellow eyes compared to the normal control eyes (p < 0.001, p < 0.01). The acqueous flare intensity significantly increased in PEX syndrome (p < 0.01). There was a significantly inverse correlation between the corneal endothelial cell density and the aqueous flare intensity in PEX.
Conclusion:
A decrease in corneal endothelial cells was quantitatively identified in PEX syndrome. This change might have a relationship with a disorder of the blood-aqueous barrier in this syndrome.