Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

LC/MS applications in drug development.

M S Lee1, E H Kerns

  • 1Milestone Development Services, Pennington, New Jersey 08534-0813, USA.

Mass Spectrometry Reviews
|November 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physicochemical profiling: overview of the screens.

Drug discovery today. Technologies·2014
Same author

High throughput physicochemical profiling for drug discovery.

Journal of pharmaceutical sciences·2001
Same author

Monitoring in vitro experiments using microdialysis sampling on-line with mass spectrometry.

Journal of pharmaceutical and biomedical analysis·2000
Same author

Hemichoreoathetosis following posterior parietal watershed infarction: was striatal hypoperfusion really to blame?

Movement disorders : official journal of the Movement Disorder Society·2000
Same author

Allogeneic hematopoietic transplantation for mantle-cell lymphoma: molecular remissions and evidence of graft-versus-malignancy.

Annals of oncology : official journal of the European Society for Medical Oncology·2000
Same author

Variability of polymerase chain reaction detection of the bcl-2-IgH translocation in an international multicentre study.

Annals of oncology : official journal of the European Society for Medical Oncology·2000

High-performance liquid chromatography and mass spectrometry (LC/MS) accelerates drug development by providing essential data for drug analysis. Advanced LC/MS techniques, including automation, are now integral to pharmaceutical research and development.

Area of Science:

  • Analytical Chemistry
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • High-performance liquid chromatography and mass spectrometry (LC/MS) has revolutionized drug development over the last decade.
  • Advancements in LC/MS technology and its applications have been driven by breakthroughs in combinatorial chemistry and molecular biology.
  • The rapid generation of samples in drug discovery necessitates efficient analytical methods.

Purpose of the Study:

  • To review the utility of LC/MS techniques in accelerating drug development.
  • To provide a perspective on the evolving strategies in pharmaceutical analysis.
  • To discuss future applications and industry trends of LC/MS in drug development.

Main Methods:

  • LC/MS-based methodologies incorporating automation, predictive/surrogate models, and open-access systems.

Related Experiment Videos

  • Qualitative and quantitative structure analysis using advanced LC/MS interface technologies.
  • Leveraging retention time and molecular weight as key analytical features.

    • Main Results:

    • LC/MS has become an indispensable tool in the pharmaceutical industry, enabling rapid analysis of drugs and related substances.
    • The integration of LC/MS has led to an iterative cycle of "what is it?" and "how much is there?" analysis.
    • New analytical paradigms have been developed to address the increasing rate of sample generation.

    Conclusions:

    • LC/MS is a critical component of modern drug development, facilitating accelerated timelines.
    • The continuous evolution of LC/MS technologies supports the growing demands of the pharmaceutical industry.
    • Future applications of LC/MS are expected to further enhance drug discovery and development processes.