Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholesterol lowering with high-viscosity hydroxypropylmethylcellulose.

K C Maki1, M H Davidson, K C Malik

  • 1Chicago Center for Clinical Research, Illinois 60610, USA.

The American Journal of Cardiology
|November 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of potato resistant starch intake on insulin sensitivity, related metabolic markers and appetite ratings in men and women at risk for type 2 diabetes: a pilot cross-over randomised controlled trial.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2020
Same author

Corn oil intake favorably impacts lipoprotein cholesterol, apolipoprotein and lipoprotein particle levels compared with extra-virgin olive oil.

European journal of clinical nutrition·2016
Same author

The Clinical Utility of a Low Serum Ceruloplasmin Measurement in the Diagnosis of Wilson Disease.

Irish medical journal·2016
Same author

Safety and lipid-altering efficacy of a new omega-3 fatty acid and antioxidant-containing medical food in men and women with elevated triacylglycerols.

Prostaglandins, leukotrienes, and essential fatty acids·2015
Same author

Maternal serum cholesterol levels are elevated from the 1st trimester of pregnancy: a cross-sectional study.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2012
Same author

Chitin-glucan fiber effects on oxidized low-density lipoprotein: a randomized controlled trial.

European journal of clinical nutrition·2012

Hydroxypropylmethylcellulose (HPMC) effectively lowers LDL cholesterol in individuals with mild to moderate hypercholesterolemia. This food gum, when used as a dietary adjunct, demonstrated significant cholesterol reduction with good tolerability.

Area of Science:

  • Nutrition Science
  • Cardiovascular Health
  • Food Chemistry

Background:

  • Hydroxypropylmethylcellulose (HPMC) shares properties with soluble fibers known to reduce cholesterol.
  • Hypercholesterolemia management often involves dietary interventions and adjunct therapies.

Purpose of the Study:

  • To evaluate the safety and cholesterol-lowering efficacy of HPMC in patients with mild to moderate hypercholesterolemia.
  • To compare HPMC's effects against a placebo within a National Cholesterol Education Program Step I diet framework.

Main Methods:

  • 160 patients with mild to moderate hypercholesterolemia were enrolled after an 8-week dietary lead-in.
  • Participants were randomized to receive placebo or varying doses of HPMC (2.5, 5.0, 7.5 g/day) for 6 weeks.
  • Lipid profiles and safety assessments were conducted bi-weekly.

Related Experiment Videos

Main Results:

  • HPMC significantly reduced total, LDL, and non-HDL cholesterol levels.
  • Doses of 5.0 and 7.5 g/day of HPMC showed statistically significant LDL cholesterol reductions compared to placebo.
  • No significant differences were observed in HDL cholesterol, triglycerides, or adverse event incidence across groups.

Conclusions:

  • HPMC is a well-tolerated and effective dietary adjunct for lowering LDL cholesterol.
  • The study supports the use of HPMC in managing mild to moderate hypercholesterolemia.
  • Further research may explore optimal dosing and long-term effects.