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Related Experiment Videos

Interactions between tazarotene and ultraviolet light.

D Hecker1, J Worsley, G Yueh

  • 1Department of Dermatology, The Mount Sinai School of Medicine, New York, NY, USA.

Journal of the American Academy of Dermatology
|November 26, 1999
PubMed
Summary
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Tazarotene pretreatment reduces the required UVB and UVA light doses for phototherapy in psoriasis patients. This combination therapy may necessitate lower initial light dosages to prevent burns and tanning.

Area of Science:

  • Dermatology
  • Photobiology
  • Pharmacology

Background:

  • Psoriasis treatment often involves phototherapy (UVB or UVA).
  • Tazarotene is a topical retinoid used for psoriasis.
  • Combining tazarotene with phototherapy is a clinical practice.

Purpose of the Study:

  • To determine the effect of tazarotene pretreatment on phototherapy dosage.
  • To assess the minimal erythema dose (MED) for UVB and immediate pigment darkening dose for UVA.
  • To evaluate the photostability of tazarotene during phototherapy.

Main Methods:

  • Tazarotene 0.1% gel applied 3 times/week for 2 weeks before phototherapy.
  • MED for UVB and UVA immediate pigment darkening dose measured.
  • Photostability of tazarotene assessed with UVB and UVA exposure.

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Main Results:

  • Tazarotene pretreatment significantly reduced MED for UVB (56.25 to 42.50 mJ/cm²) and UVA immediate pigment darkening dose (20.18 to 18.50 J/cm²).
  • Immediate thin tazarotene application had no significant effect on UVB MED.
  • Thick tazarotene application slightly increased UVB MED.
  • Tazarotene demonstrated chemical stability with UVB and UVA.

Conclusions:

  • Pretreatment with tazarotene lowers sensitivity to UVB and UVA radiation.
  • Initiating UVB phototherapy at 50-75% of MED and PUVA at lower doses is recommended with tazarotene.
  • Lower overall UVA/UVB doses may be required for psoriasis patients receiving concomitant tazarotene therapy.