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Biotransformation of N-acetylphenothiazine by fungi
I A Parshikov1, J P Freeman, A J Williams
1Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA.
Applied Microbiology and Biotechnology
|November 26, 1999
Abstract:
Cultures of the fungi Aspergillus niger, Cunninghamella verticillata, and Penicillium simplicissimum, grown in a sucrose/peptone medium, transformed N-acetylphenothiazine to N-acetylphenothiazine sulfoxide (from 13% to 28% of the total) and phenothiazine sulfoxide (from 5% to 27%). Phenothiazin-3-one (4%) and phenothiazine N-glucoside (4%) were also produced by C. verticillata. The probable intermediate, phenothiazine, was detected only in cultures of P. simplicissimum (6%).