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The human caspase-activated DNase gene (hCAD): genomic structure, exonic single-nucleotide polymorphisms, and a
N Sugimoto1, Y Fukuda, F Saito-Ohara
1Department of Molecular Cytogenetics, Tokyo Medical and Dental University, Japan.
Journal of Human Genetics
|November 26, 1999
Abstract:
Caspase-activated DNase (CAD) cleaves chromosomal DNA during apoptosis. We determined its genomic structure and identified single-nucleotide polymorphisms (SNPs) within exons 5 and 7, as well as a highly polymorphic dinucleotide repeat of (CT)m(CA)n within the 5' region of the human CAD gene (hCAD). The genomic structure of hCAD presented here, together with information concerning SNPs within the gene, as well as a highly polymorphic (CT)m(CA)n repeat fragment at the hCAD locus, may assist in the construction of genetic maps for exploring gene(s) that play pivotal roles in carcinogenesis.