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New pyrrole derivatives as antimycobacterial agents analogs of BM212
M Biava1, R Fioravanti, G C Porretta
1Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università La Sapienza, Rome, Italy. Biava@axrma.uniroma1.it
Bioorganic & Medicinal Chemistry Letters
|November 26, 1999
Abstract:
During the course of our investigations in the field of azole antimicrobial agents, we have identified BM212 a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 2-6 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.