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A new approach to the synthesis of efaroxan
K Couture1, V Gouverneur, C Mioskowski
1Laboratoire de Synthèse Bio-Organique, CNRS et Université Louis Pasteur, Faculté de Pharmacie 74, Illkirch-Graffenstaden, France.
Bioorganic & Medicinal Chemistry Letters
|November 26, 1999
Abstract:
Efaroxan was synthetised by cyclisation of the tertiary alcohol 2 which was prepared by the ring opening of the gem-disubstituted epoxide 3 with ortho-metallated fluorobenzene.