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Fungal susceptibility testing.

M A Gianinni1, T Pearson, C C Patrick

  • 1Department of Pathology & Molecular Microbiology, St. Jude Children's Research Hospital, TN, USA.

The Pediatric Infectious Disease Journal
|November 26, 1999
PubMed
Summary
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Antifungal susceptibility testing is not routinely recommended due to undetermined utility. However, testing may be valuable for specific fungal infections like Candida and Pseudallescheria boydii, and for novel fungal pathogens.

Area of Science:

  • Medical Mycology
  • Clinical Microbiology
  • Antimicrobial Resistance

Background:

  • The clinical utility of antifungal susceptibility testing (AFST) remains largely undetermined.
  • Routine AFST is not currently recommended for most fungal infections.
  • Variability in antifungal drug response necessitates careful consideration of testing.

Purpose of the Study:

  • To evaluate the circumstances under which antifungal susceptibility testing is beneficial.
  • To guide the appropriate application of AFST in clinical settings.
  • To address the need for susceptibility data in emerging fungal diseases.

Main Methods:

  • Review of current clinical guidelines and literature on AFST.
  • Analysis of specific fungal pathogens where AFST has demonstrated value.

Related Experiment Videos

  • Consideration of emerging fungal threats and the role of susceptibility data.

    • Main Results:

    • AFST is not recommended routinely but has utility in select cases.
    • Testing is valuable for certain Candida species and Pseudallescheria boydii infections.
    • Susceptibility testing to azoles is particularly important for yeasts due to variable responses.

    Conclusions:

    • Antifungal susceptibility testing should be considered selectively, not routinely.
    • Testing is crucial for novel fungal pathogens lacking clinical efficacy data.
    • Targeted AFST can inform antifungal therapy choices for specific infections.