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Comparison of an antiviral activity of recombinant consensus interferon with recombinant interferon-alpha-2b
A H Koyama1, T Arakawa, A Adachi
1Department of Virology, School of Medicine, The University of Tokushima, Japan.
Abstract:
To avoid possible uncertainty in comparing biological activities of interferon samples from different sources where interferon concentrations were determined independently, we prepared chromatographically pure preparations of consensus interferon and interferon-alpha-2b (one of the two commercially available recombinant alpha interferons). We revealed that consensus interferon has a stronger antiviral activity than interferon-alpha-2b, although the effects of these two recombinant interferons on the cellular macromolecule synthesis are at similar levels.
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