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Related Experiment Videos

Testing hair for pharmaceuticals.

Y Gaillard1, G Pépin

  • 1Laboratoire d'Expertises TOXLAB, Paris, France.

Journal of Chromatography. B, Biomedical Sciences and Applications
|November 26, 1999
PubMed
Summary
This summary is machine-generated.

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This review covers the analysis of 90 drugs and metabolites in human hair using chromatography. Advanced techniques improve the detection of low-dose drugs, showing progress in forensic toxicology.

Area of Science:

  • Forensic Chemistry
  • Analytical Chemistry
  • Toxicology

Background:

  • Human hair analysis is crucial for detecting drug use, abuse, and doping.
  • Over a hundred pharmaceuticals, drugs of abuse, and doping agents are detectable in hair.
  • Chromatographic procedures are standard for analyzing these substances in hair.

Observation:

  • This review examines the analysis of 90 drugs and their metabolites in human hair.
  • It details pretreatment, extraction methods, limits of detection, and concentrations in real samples.
  • Progress in detecting low-dose drugs like fentanyl and flunitrazepam is noted.

Findings:

  • Sophisticated techniques such as Gas Chromatography-Mass Spectrometry-Negative Ion Chemical Ionization (GC-MS-NCI), High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS), and Gas Chromatography-Mass Spectrometry-Mass Spectrometry (GC-MS-MS) are increasingly employed.

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  • These advanced methods demonstrate a continuous effort to enhance sensitivity in drug detection.
  • The authors include novel findings based on their recent practical experience.

    • Implications:

    • Improved analytical sensitivity aids in identifying drug use, abuse, and doping with greater accuracy.
    • The findings support the ongoing development of more sensitive methods for forensic and clinical toxicology.
    • Enhanced detection capabilities are vital for legal, medical, and anti-doping applications.