Bone mineral density in steroid-dependent asthma assessed by peripheral quantitative computed tomography

¹Division of Medicine, Okayama University Medical School, Tottori, Japan.

|November 26, 1999

Summary

Systemic glucocorticoid therapy causes bone loss, affecting both trabecular and cortical bone density. This loss, particularly in older patients, increases fracture risk, highlighting the need for monitoring bone health during long-term steroid use.

Area of Science:

Endocrinology
Bone Metabolism
Pharmacology

Background:

Chronic systemic glucocorticoid use is a significant cause of bone loss and fractures.
Understanding the predictive factors for glucocorticoid-induced bone loss is crucial for patient management.

Purpose of the Study:

To identify variables predicting bone loss in patients on systemic glucocorticoid therapy.
To quantify changes in cortical and trabecular bone using peripheral quantitative computed tomography (pQCT).

Main Methods:

Eighty-four asthmatic patients receiving systemic glucocorticoid therapy were studied.
Peripheral quantitative computed tomography (pQCT) measured bone mineral density (BMD) in cortical and trabecular bone.
Multiple regression analysis identified predictive variables for bone loss.

Main Results:

Cumulative glucocorticoid dose correlated with decreased bone mineral density (p<0.05) and trabecular bone density (p<0.01).
In patients aged 65 and older, cumulative dose correlated with vertebral fractures, total BMD, and cortical BMD (p<0.05, p<0.01).
Glucocorticoid therapy reduced both trabecular and cortical bone mineral density, with cortical bone loss potentially explaining increased fracture incidence.

Conclusions:

Systemic glucocorticoids negatively impact both trabecular and cortical bone density.
Loss of cortical bone, essential for skeletal strength, is implicated in the elevated fracture risk associated with long-term glucocorticoid treatment.
Monitoring bone density, especially cortical bone, is vital in patients undergoing chronic glucocorticoid therapy.

Related Experiment Videos

Bone mineral density in steroid-dependent asthma assessed by peripheral quantitative computed tomography

Related Concept Videos

Fermented milk retains beneficial effects on skeletal muscle protein anabolism after processing by centrifugation and supernatant removal.

A case of nivolumab-induced acute-onset type 1 diabetes mellitus in melanoma.

Effects of Low-Dose Dairy Protein Plus Micronutrient Supplementation during Resistance Exercise on Muscle Mass and Physical Performance in Older Adults: A Randomized, Controlled Trial.

Randomised clinical trial: vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the healing of erosive oesophagitis.

Randomised clinical trial: a dose-ranging study of vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the treatment of erosive oesophagitis.

Randomised clinical trial: safety, tolerability, pharmacokinetics and pharmacodynamics of repeated doses of TAK-438 (vonoprazan), a novel potassium-competitive acid blocker, in healthy male subjects.

A phase 2a, double-blind, randomised, placebo-controlled trial of the myeloperoxidase inhibitor, mitiperstat, in participants with chronic obstructive pulmonary disease.

Preclinical models of COPD: a state of the art.

Improved Outcomes with Early Aggressive Therapy in Pediatric Pulmonary Hypertension.

Association of Positive airway pressure adherence with mortality and cardiovascular events in high vs low risk sleep apnoea patients.

Characterization of Airway Morphology in Post-infectious versus Post-lung Transplant Bronchiolitis Obliterans.

ERS/ESCMID state-of-the-science statement on the role of rapid diagnostic tests for the diagnosis and management of community-acquired lower respiratory tract infections.

Factors associated with the presence, and longitudinal progression of, perivascular spaces: An Exposome-Wide Analysis in the UK Biobank.

Chronic Cough With Reduced Diffusing Capacity and Preserved-Ratio Impaired Spirometry in a Young Never-Smoker With Systemic Lupus Erythematosus: A Diagnostic Pitfall.

Dynamic Assessment of Cortical Porosity in Preclinical Models: Time-lapse Imaging of Cortical Remodeling.

Inhalable solid lipid nanoparticles of cyclosporine A for prolonged pulmonary exposure: nano-in-micro particles prepared with fine droplet drying process.

Hybrid generative modeling with transformer-based classification for medical image-based silicosis detection.

Linking Laboratory and Field Observations of Carbon Dioxide Transport at the Nevada National Security Site.

Related Experiment Videos

Bone mineral density in steroid-dependent asthma assessed by peripheral quantitative computed tomography

Area of Science:

Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions:

Related Concept Videos

Related Articles