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Related Experiment Videos

Morphine and gastroduodenal motility.

T D Lewis1

  • 1Division of Gastroenterology, Jerry L. Pettis Memorial Veterans Medical Center, Loma Linda, California 92354, USA.

Digestive Diseases and Sciences
|November 26, 1999
PubMed
Summary

Intravenous morphine stimulates duodenal motility, inducing phase III-like contractions. This effect is mediated by opioid receptors and blocked by antimuscarinic drugs, highlighting morphine

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Area of Science:

  • Gastroenterology
  • Pharmacology
  • Neurogastroenterology

Background:

  • Opioid analgesics like morphine can affect gastrointestinal function.
  • Understanding morphine's impact on duodenal motility is crucial for clinical practice.

Purpose of the Study:

  • To investigate the effects of intravenous morphine on gastric antral and duodenal motility.
  • To characterize the nature of morphine-induced duodenal contractions and their underlying mechanisms.

Main Methods:

  • Healthy volunteers received intravenous morphine via infusion or bolus injection.
  • Duodenal motility was monitored, and the effects of naloxone and atropine were assessed.
  • Morphine's action was studied following spontaneous phase III activity and after a liquid meal.

Main Results:

  • Intravenous morphine significantly increased duodenal motility, inducing phase III-like contractions.
  • Naloxone, an opioid receptor antagonist, blocked morphine's effect.
  • Atropine, an antimuscarinic agent, prevented morphine-induced duodenal activity.

Conclusions:

  • Low-dose intravenous morphine potently stimulates duodenal contractility in a phase III-like manner.
  • Morphine initiates this response via opioid receptors.
  • The effect is mediated through a pathway sensitive to antimuscarinic drugs.

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