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Radiotherapy of malignant lymphomas
Acta Neuropathologica. Supplementum
|January 1, 1975
Summary
Radiotherapy effectively treats central nervous system (CNS) non-Hodgkin lymphomas, improving outcomes for acute leukemia and solitary tumors. Doses should be carefully managed, with prophylactic irradiation covering the entire subarachnoid space.
Area of Science:
- Radiation oncology
- Neurology
- Hematology
Background:
- Non-Hodgkin's lymphomas can affect the central nervous system (CNS).
- Treatment of CNS lymphomas involves radiotherapy and chemotherapy.
Purpose of the Study:
- To outline radiotherapy principles for CNS lymphomas.
- To discuss prophylactic and therapeutic applications of radiotherapy in CNS lymphomas.
Main Methods:
- Fractionated radiotherapy with dose escalation.
- Prophylactic irradiation of the entire subarachnoid space for systemic disease.
- Treatment of focal CNS lesions based on tumor morphology.
Main Results:
- Radiotherapy significantly improves outcomes when combined with intrathecal chemotherapy, especially in childhood CNS leukemia.
- Total doses should not exceed 2,500 rd.
- Rare primary CNS tumors with lymphoma-sarcoma or reticulosarcoma features show the best prognostic response to radiotherapy.
Conclusions:
- Radiotherapy is a cornerstone in managing CNS lymphomas.
- Careful dose fractionation and target volume delineation are crucial for effective treatment.
- Further exploration of prophylactic radiotherapy in other reticuloendothelial system (RES) diseases is warranted.
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