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[Hürthle-cell thyroid neoplasms: a clinical enigma].
M Cannizzaro1, G Fiorenza, L Garofalo
1Istituto di Patologia Chirurgica III, Università degli Studi di Catania.
Annali Italiani Di Chirurgia
|November 26, 1999
Summary
Hürthle cell neoplasms, a challenging thyroid tumor type, require tailored treatment. Surgery choice depends on malignancy, with lobo-isthmectomy for benign nodules and total thyroidectomy for malignant ones, alongside long-term monitoring.
Area of Science:
- Endocrinology
- Surgical Oncology
- Pathology
Context:
- Hürthle cell neoplasms are a subset of thyroid tumors with diagnostic and therapeutic uncertainties.
- They represent 1.5% to 10% of all thyroid neoplasms.
- Distinguishing benign from malignant Hürthle cell nodules histologically can be difficult.
Purpose:
- To analyze the clinical experience with Hürthle cell adenomas and suggest optimal treatment strategies.
- To evaluate the efficacy of surgical interventions and long-term follow-up for these neoplasms.
Summary:
- The study reviewed nine cases of Hürthle cell adenomas among 335 surgical thyroid diseases.
- Treatment varied, including total thyroidectomy and lobo-isthmectomy, based on concomitant thyroid conditions.
- Long-term follow-up showed no recurrence of neoplastic disease.
Impact:
- Recommends lobo-isthmectomy for definitively benign Hürthle cell nodules.
- Advocates for total thyroidectomy with lymphadenectomy for malignant Hürthle cell tumors if nodes are metastatic.
- Emphasizes the importance of long-term surveillance for all patients with Hürthle cell neoplasms.