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Published on: September 9, 2015
[Biliary diffusion of tazocillin in man].
J M Brogard1, F Caro-Sampara, J F Westphal
1Département de Médecine Interne de la Clinique Médicale B, Centre Hospitalo-Universitaire de Strasbourg, France.
Pathologie-Biologie
|November 26, 1999
Summary
This study measured piperacillin and tazobactam levels in bile and gallbladder tissue after tazocillin infusion. High concentrations suggest tazocillin is effective for treating biliary tract infections.
Area of Science:
- Pharmacology
- Hepatobiliary Medicine
- Infectious Diseases
Background:
- Biliary tract infections are a significant clinical concern.
- Understanding antibiotic penetration into bile is crucial for effective treatment.
- Tazocillin, a combination of piperacillin and tazobactam, is frequently used for bacterial infections.
Purpose of the Study:
- To quantify the biliary excretion of piperacillin and tazobactam after intravenous tazocillin administration.
- To assess the concentrations of these antibiotics in bile and gallbladder wall tissue.
- To evaluate the potential of tazocillin in managing biliary infections.
Main Methods:
- Piperacillin and tazobactam levels were measured in serum, bile, and gallbladder wall in patients undergoing cholecystectomy.
- HPLC was utilized for the quantitative analysis of both drugs.
- Bile samples were also collected via T-tube drainage over 12 hours post-infusion.
Main Results:
- High concentrations of piperacillin and tazobactam were detected in main bile duct bile, gallbladder bile, and gallbladder wall.
- Peak levels in T-tube bile were observed within 1 hour post-infusion.
- Total biliary excretion represented a small percentage of the administered dose over 12 hours.
Conclusions:
- The substantial levels of piperacillin and tazobactam in biliary tissues suggest good penetration.
- These findings support the potential efficacy of tazocillin for the prevention and treatment of biliary infections.
- Further clinical studies may confirm tazocillin's role in managing hepatobiliary infections.
