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Hemispheric differences on auditory evoked response suppression in schizophrenia.

L D Blumenfeld1, B A Clementz

  • 1Department of Psychology, University of California, San Diego, La Jolla 92093-0109, USA.

Neuroreport
|November 26, 1999
PubMed
Summary

Schizophrenia patients show impaired auditory evoked response (AER) suppression, particularly with binaural stimuli. This auditory processing deficit, especially in M100 suppression, highlights potential hemispheric differences in schizophrenia.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Auditory Neuroscience

Background:

  • Schizophrenia is associated with auditory processing deficits.
  • Previous studies indicate impaired auditory evoked response (AER) suppression in schizophrenia using binaural stimuli.

Purpose of the Study:

  • To investigate hemispheric differences in AER suppression between schizophrenia patients and normal subjects.
  • To compare AER suppression using monaural and binaural stimulus presentation.

Main Methods:

  • Recorded auditory evoked responses from 12 schizophrenia and 12 normal subjects using a 148-channel whole-head biomagnetometer.
  • Presented 120 pairs of clicks in left, right, and binaural conditions.
  • Analyzed M100 suppression and gamma band response suppression.

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Main Results:

  • Schizophrenia patients exhibited worse M100 suppression than controls in the ipsilateral hemisphere with monaural stimuli (effect size -2.13).
  • No significant group differences were found in contralateral M100 suppression or gamma band response suppression.
  • Binaural stimulus presentation yielded the best group separation for M100 suppression (effect size -4.14).

Conclusions:

  • Schizophrenia is characterized by impaired auditory evoked response suppression, particularly M100 suppression.
  • Hemispheric differences in auditory processing may exist in schizophrenia.
  • Binaural stimulus presentation is most effective for detecting AER suppression deficits in schizophrenia.