Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The host immune response in human osteosarcoma.

J H McMaster, R J Ferguson, C R Weinert

    Clinical Orthopaedics and Related Research
    |September 11, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer: Aggregate data and individual patient data meta-analyses.

    Clinical psychology review·2020
    Same author

    Primary stability of a short bone-conserving femoral stem: a two-year randomized controlled trial using radiostereometric analysis.

    The bone & joint journal·2018
    Same author

    Infographic: Primary stability of a short bone-conserving femoral stem.

    The bone & joint journal·2018
    Same author

    Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer: An individual patient data meta-analysis of 22 RCTs.

    Psycho-oncology·2018
    Same author

    Echocardiography and the Athlete's Heart.

    The Physician and sportsmedicine·2016
    Same author

    Unusual lesions of the patella.

    Orthopedics·2014

    Osteosarcoma patients show normal immune responses but cannot target their own tumor cells. This study reveals no common sarcoma antigen and occasional presence of serum blocking factors affecting immune response.

    Area of Science:

    • Immunology
    • Oncology
    • Cell Biology

    Background:

    • Patient prognosis is significantly influenced by the immunologic response to malignant tumors.
    • Understanding the cellular and serum factors in immune responses is crucial for cancer treatment.

    Purpose of the Study:

    • To quantitatively evaluate the role of cell-mediated and serum factors in osteosarcoma patients' immune responses.
    • To develop a reliable in vitro microcytotoxicity assay for assessing anti-tumor immunity.

    Main Methods:

    • Developed an in vitro microcytotoxicity assay using cultured tritiated thymidine (3HT)-labeled osteosarcoma cells and autologous fibroblasts.
    • Quantitatively evaluated cell-mediated cytotoxicity and the presence of serum factors.
    • Assessed the ability of patient lymphocytes to differentiate and target tumor cells versus autologous fibroblasts.

    Related Experiment Videos

    Main Results:

    • Osteosarcoma patients exhibit normal cellular immune responses with non-specific in vitro cytotoxicity.
    • Patients' immune cells could not differentiate between autologous tumor cells and fibroblasts.
    • Serum blocking factors, inhibiting lymphocyte-mediated cytotoxicity, were occasionally detected.

    Conclusions:

    • Osteosarcoma is not caused by host immune incompetence.
    • A common sarcoma antigen does not appear to exist.
    • Serum blocking factors may occasionally play a role in modulating the immune response in osteosarcoma.