Related Experiment Videos
Comparative irritancy study among retinoid creams and gels
J W Toole1, L Lockhart, J Potrebka
1Hill Top Research, Inc., Winnipeg, Manitoba.
Journal of Cutaneous Medicine and Surgery
|November 27, 1999
Summary
Adapalene cream and gel showed less skin irritation compared to tretinoin products in a human study. This finding is significant for topical retinoid use in dermatology.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Research
Background:
- Topical retinoids are valuable dermatological treatments.
- Patient irritation is a common issue with topical retinoid use.
Purpose of the Study:
- To evaluate the human irritancy potential of topical retinoid gels and creams available in Canada.
- Compare the irritancy of adapalene versus tretinoin formulations.
Main Methods:
- Thirty healthy adults participated in the study.
- Ten products, including adapalene, tretinoin, petrolatum, and sodium lauryl sulfate (SLS), were applied for up to 21 days.
- Irritation severity and early termination rates were recorded.
Main Results:
- Adapalene and petrolatum caused significantly less irritation than tretinoin products and SLS (p = .001).
- Statistically significant differences in irritation severity favored adapalene over tretinoin formulations (p = .0001).
- Early study termination due to irritation was more frequent with tretinoin and SLS.
Conclusions:
- Adapalene cream and gel demonstrate lower irritancy upon multiple applications compared to various tretinoin formulations.
- Adapalene presents a potentially better-tolerated option for patients requiring topical retinoid therapy.