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Related Experiment Videos

Economic issues in postexposure rabies treatment.

H Wilde1, P Tipkong, P Khawplod

  • 1Queen Saovabha Memorial Institute (WHO Collaborating Center for Research in Rabies) and the Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.

Journal of Travel Medicine
|November 27, 1999
PubMed
Summary

Rabies control faces challenges from dog management issues and high treatment costs. Affordable, effective rabies vaccines and treatments are crucial for global public health, especially for travelers.

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Area of Science:

  • Veterinary Medicine
  • Public Health
  • Epidemiology

Background:

  • Rabies continues to be a significant global public health concern.
  • Challenges in controlling rabies include logistical and cultural barriers to dog management, and the high cost of human postexposure prophylaxis.
  • Previous efforts to reduce the cost of rabies vaccines and immune globulin have had limited success.

Purpose of the Study:

  • To review the current status of rabies control strategies.
  • To evaluate the effectiveness and affordability of newer rabies vaccines and treatment protocols.
  • To provide recommendations for rabies prevention, particularly for travelers.

Main Methods:

  • Review of existing literature on rabies vaccines, immune globulin, and postexposure prophylaxis.

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  • Analysis of cost-effectiveness and safety data for different rabies control interventions.
  • Examination of regional successes in rabies control, such as in Thailand, the Philippines, and Sri Lanka.

    • Main Results:

    • Second-generation rabies vaccines (Vero cell, chick embryo, duck embryo) are effective, safe, and more affordable than human diploid cell rabies vaccine.
    • Reduced-dose intradermal postexposure vaccination is an effective and affordable strategy, replacing dangerous brain tissue-derived vaccines in some regions.
    • Purified equine rabies immune globulin is safe and cost-effective but faces global supply shortages.

    Conclusions:

    • Advancements in rabies vaccines and vaccination strategies offer more affordable and effective control measures.
    • Intradermal vaccination protocols present a viable, cost-effective option for postexposure prophylaxis.
    • Preexposure vaccination, preferably via the intramuscular route, is recommended for individuals traveling to rabies-endemic areas.