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Updated: Oct 18, 2026
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region
U Mahlknecht1, R Bucala, D Hoelzer
1Laboratory of Medical Biochemistry, The Picower Institute for Medical Research, Manhasset NY, USA. Mahlknecht@em.uni-frankfurt.de
Abstract:
Histone deacetylases have been described as crucial cofactors of mammalian transcriptional complexes. We have recently identified human histone deacetylase HDAC3 on chromosome 5q31 by fluorescence in situ hybridization (FISH) in a region commonly deleted in malignant myeloid disease. Since HDAC3 carries strong potential to be a tumor suppressor gene, we report herein its exact position between the CD14 and GRIA1 genes within the 5q31.1 subband.
