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Published on: November 1, 2015
Clinicopathologic correlations in lupus nephritis in Lima, Peru
A Hurtado1, C Asato, E Escudero
1Division of Nephrology, Hospital Loayza, Cayetano Heredia University, Lima, Peru.
Nephron
|November 27, 1999
Summary
Interstitial macrophages in lupus nephritis correlate with renal function, unlike glomerular macrophages. This finding suggests interstitial macrophages may be a better indicator of disease activity and prognosis than current classifications.
Area of Science:
- Nephrology
- Immunology
- Pathology
Background:
- Lupus nephritis diagnosis relies on WHO classification and NIH indices.
- Immunohistologic markers may offer better correlation with renal function and disease activity.
Purpose of the Study:
- To assess immunohistologic markers for glomerular and tubulointerstitial injury.
- To compare these markers with WHO and NIH classifications for lupus nephritis.
Main Methods:
- 33 lupus nephritis patients underwent renal biopsy.
- Evaluated macrophages, proliferating cells, alpha-actin, and type IV collagen.
- Compared findings with WHO and NIH classifications.
Main Results:
- WHO class IV correlated with lower complement, higher proteinuria/hematuria, and worse renal function.
- NIH activity and chronicity indices correlated with clinical findings and renal function.
- Interstitial macrophages correlated with renal function and nephrotic syndrome, unlike glomerular macrophages.
Conclusions:
- WHO and NIH indices correlate with lupus nephritis clinical manifestations.
- Interstitial macrophages, but not glomerular macrophages, correlate with renal function.
- Interstitial macrophages may be a valuable prognostic marker for lupus nephritis.
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