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Aggregation inhibitory activity of minor acetophenones from Paeonia species
1School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. hcl@ndmcl.ndmctsgh.edu.tw
Planta Medica
|November 27, 1999
Abstract:
Two minor acetophenones, 2,5-dihydroxy-4-methoxy-acetophenone (2) and 2,5-dihydroxy-4-methylacetophenone (7) from Paeonia species were found to selectively inhibit the aggregation of rabbit platelets induced by arachidonic acid. They were more potent than the major compound, paeonol (1), and 7 also inhibited the formation of TXA2 and PGD2 from arachidonic acid.