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[Community effectiveness of vaccines against infectious parotiditis (mumps). Report of cases]
J Limón Mora1, T Molina López, J C Domínguez Camacho
1Unidad de Epidemiología Distrito Sanitario A.P. Sevilla Este. jlimon@cica.es
Background:
In our country, there are two types of infectious mumps vaccines available. In recent times, doubts have been raised regarding the overall effectiveness of these vaccines and the comparative effectiveness of the two strains (Rubini strain and Jeryl Lynn strain). In the "East Seville" Primary Care district, 245 cases were reported in 1997 (90.1 cases per 100,000 inhabitants). This study is aimed at taking advantage of the outbreak of cases of mumps to evaluate affected populations and comparative incidence according to type of vaccines given during childhood.
Methods:
Descriptive analysis of the cases (age, territorial spread, inoculation history') and trend analysis (annual incident rates) within this health care district and the surrounding area. The overall effectiveness of the mumps vaccines. The case incidence rates among those inoculated with Rubini strain and those inoculated with Jeryl Lynn strain are also estimated.
Results:
The highest rates of incidence are found among children in the 1-4 age range. Overall effectiveness rates for these vaccines have been estimated. A significantly higher rate of infection has been found among the children inoculated with Rubini strain than those inoculated with the Jeryl Lynn strain (relative risk of 6.5 with a Confidence Interval of 95% 3.6-11.8).
Conclusions:
The effectiveness which follows from this study does not seem as good as the theoretical effectiveness anticipated for the mumps vaccines. It thus seems advisable for other case studies to be conducted by types of vaccines used. The data to be furnished by means of sero-epidemiological studies are also of major interest.
Insights
Mumps vaccine effectiveness is lower than expected, with the Rubini strain showing significantly lower protection than the Jeryl Lynn strain. Further studies on vaccine types are recommended.
Area of Science:
- Epidemiology
- Vaccinology
Context:
- Two infectious mumps vaccines are available, with questions arising about their effectiveness.
- A 1997 mumps outbreak in
- East Seville
- Primary Care district reported 245 cases.
Purpose:
- To evaluate affected populations during a mumps outbreak.
- To compare the incidence rates between Rubini and Jeryl Lynn mumps vaccine strains.
- To assess the overall effectiveness of mumps vaccines.
Summary:
- Incidence rates were highest in children aged 1-4.
- Overall vaccine effectiveness was estimated.
- The Rubini strain demonstrated significantly lower effectiveness compared to the Jeryl Lynn strain (RR 6.5, 95% CI 3.6-11.8).
Impact:
- Mumps vaccine effectiveness appears lower than theoretically anticipated.
- Further case studies comparing vaccine types are warranted.
- Sero-epidemiological studies are crucial for understanding vaccine performance.