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Related Experiment Videos

Amnion-chorion separation after 17 weeks' gestation.

B Bromley1, T D Shipp, B R Benacerraf

  • 1Department of Obstetrics & Gynecology, Massachusetts General Hospital, Brigham & Women's Hospital, Harvard Medical School, Boston, USA. bbsono@aol.com

Obstetrics and Gynecology
|November 27, 1999
PubMed
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Persistent amnion-chorion separation after 17 weeks gestation is linked to adverse perinatal outcomes. This condition, identified via ultrasound, can indicate potential fetal aneuploidy and other complications.

Area of Science:

  • Perinatology
  • Medical Imaging
  • Genetics

Background:

  • Amnion-chorion separation is a condition where the amniotic sac and the chorionic membrane separate.
  • Sonographic identification of this separation after 17 weeks gestation is uncommon.

Purpose of the Study:

  • To evaluate the causes and perinatal outcomes of sonographically apparent amnion-chorion separation after 17 weeks gestation.

Main Methods:

  • A retrospective review of ultrasound databases identified 15 pregnant women with live fetuses and complete amnion-chorion separation beyond 17 weeks gestation.
  • Medical records were analyzed for amniocentesis history, results, and pregnancy outcomes.

Main Results:

  • Ten of 15 women underwent amniocentesis prior to separation identification; five did not.

Related Experiment Videos

  • Three fetuses had Down syndrome, with two showing separation before amniocentesis.
  • Adverse outcomes included fetal growth restriction, preterm delivery, oligohydramnios, and abruptio placentae. Ten of 15 pregnancies resulted in live newborns.

    • Conclusions:

    • Complete amnion-chorion separation persisting after 17 weeks gestation is associated with adverse perinatal outcomes.
    • Aneuploidy, such as Down syndrome, is a potential complication linked to this sonographic finding.