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Effect of stobadine on oxygen free radical generation in stimulated human polymorphonuclear leukocytes
J Pecivová1, K Drábiková, K Kotuliaková
1Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic. exfajape@savba.sk
Life Sciences
|November 27, 1999
Abstract:
The generation both superoxide and a mixture of reactive oxygen species was recorded in a suspension of human polymorphonuclear leukocytes stimulated with phorbol myristate acetate. While stobadine dose-dependently decreased chemiluminescence, only its highest concentration used reduced significantly superoxide generation. The results suggest that stobadine is a more effective scavenger of free radicals rather than a quencher of superoxide anion.