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The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 18, 2013

A high proliferation rate measured by cyclin A predicts a favourable chemotherapy response in soft tissue sarcoma

R L Huuhtanen1, T A Wiklund, C P Blomqvist

  • 1Helsinki University Central Hospital, Department of Oncology, Finland.

British Journal of Cancer
|November 27, 1999
PubMed

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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