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Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based
A Hoepping1, J Babich, J A Zubieta
1Drug Discovery Program, Georgetown University Medical Center, Washington DC 20007-2197, USA.
Bioorganic & Medicinal Chemistry Letters
|November 27, 1999
Abstract:
Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.