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Effect of insulin sensitivity on pulsatile insulin secretion
M Zarković1, J Cirić, M Stojanović
1Institute of Endocrinology, School of Medicine, University of Belgrade, Dr Subotića 13, 11000 Belgrade, Yugoslavia. mzarkov@eunet.yu
European Journal of Endocrinology
|November 27, 1999
Summary
Irregular insulin secretion is linked to reduced insulin sensitivity, not just type 2 diabetes. This study shows that impaired insulin pulsatility is a broader metabolic issue.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Diabetes Research
Background:
- Insulin pulsatility, the rhythmic release of insulin, plays a crucial role in glucose homeostasis.
- Derangements in insulin secretion patterns have been observed in various metabolic conditions.
Purpose of the Study:
- To investigate the relationship between abnormal insulin pulsatility and insulin resistance.
- To determine if altered insulin secretion patterns are exclusive to non-insulin-dependent diabetes mellitus (NIDDM).
Main Methods:
- Analysis of insulin secretion patterns in 26 obese, 11 NIDDM, and 10 control subjects.
- Quantification of insulin pulse regularity using approximate entropy (ApEn) and interpulse interval deviation (IpID).
- Assessment of insulin sensitivity using the Homeostasis Model Assessment (HOMA).
Main Results:
- Insulin pulses were significantly less regular in obese individuals with high insulin levels (OHI) and NIDDM patients compared to controls and obese individuals with low insulin (OLI).
- No significant difference in pulse regularity was found between the OHI and NIDDM groups.
- Reduced insulin secretion regularity was directly correlated with decreased insulin sensitivity.
Conclusions:
- Irregular insulin secretion is associated with reduced insulin sensitivity.
- Impaired insulin pulsatility is not unique to NIDDM and is also present in insulin-resistant states.