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Related Experiment Videos

Akinetopsia from nefazodone toxicity.

J C Horton1, J D Trobe

  • 1Beckman Vision Center, University of California, San Francisco 94143-0730, USA. horton@itsa.ucsf.edu

American Journal of Ophthalmology
|November 30, 1999
PubMed
Summary
This summary is machine-generated.

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Nefazodone antidepressant toxicity can cause akinetopsia, a rare condition impairing motion perception. Patients experienced visual trails and freeze-frame images, which resolved upon dosage reduction.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Pharmacology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) and serotonin 5-HT2 receptor antagonists, like nefazodone, are widely prescribed antidepressants.
  • Visual processing disorders, such as akinetopsia, are rare but can significantly impact quality of life.

Observation:

  • Two cases of akinetopsia are reported in patients taking the antidepressant nefazodone.
  • Patients described experiencing "freeze-frame" images and visual trails following moving objects.

Findings:

  • Nefazodone toxicity was identified as the cause of akinetopsia in both cases.
  • Symptoms included the inability to perceive motion smoothly, with persistence of multiple images and visual trails.
  • Visual function normalized after nefazodone dosage was reduced or discontinued.

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Implications:

  • Nefazodone can selectively impair visual motion processing pathways, leading to akinetopsia.
  • This highlights the importance of considering medication side effects in the diagnosis of visual disturbances.
  • Further research into the neurobiological mechanisms underlying nefazodone-induced visual toxicity is warranted.