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Non-syndromic hearing impairment: gene linkage and cloning
1Department of Otolaryngology, University of Iowa, Iowa City 52242, USA. richard-smith@uiowa.edu
International Journal of Pediatric Otorhinolaryngology
|November 30, 1999
Abstract:
Non-syndromic hearing impairment (NSHI) affects approximately 1:2000 newborns and is a significant cause of hearing loss in the elderly. Although the phenotype is quite similar, NSHI is extremely heterogeneous, with over 40 genetic loci now known. A number of the relevant genes have been cloned. These advances are impacting clinical practice and revolutionizing our understanding of the biology of hearing.