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Related Experiment Videos

Two forms of reactive arthritis?

P Toivanen1, A Toivanen

  • 1Turku Immunology Centre, Departments of Medical Microbiology and Medicine, Turku University, Turku, Finland.

Annals of the Rheumatic Diseases
|December 1, 1999
PubMed
Summary

Reactive arthritis, previously termed postinfectious, should be unified under one name. This classification distinguishes between HLA-B27 associated and non-associated forms based on triggers and clinical presentation.

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Area of Science:

  • Rheumatology
  • Immunology
  • Infectious Diseases

Background:

  • Inflammatory arthritides following infection are variably termed reactive or postinfectious.
  • Current classification often depends on the microbial trigger and human leukocyte antigen B27 (HLA-B27) status.

Purpose of the Study:

  • To propose a unified nomenclature for these conditions, advocating for the term "reactive arthritis."
  • To differentiate between HLA-B27 associated and non-associated forms of reactive arthritis.

Main Methods:

  • Review of existing literature and clinical characteristics of postinfectious inflammatory arthritides.
  • Analysis of distinguishing features between HLA-B27 positive and negative cases.

Main Results:

  • The study proposes unifying "reactive" and "postinfectious" arthritis under the single term "reactive arthritis."
  • Two distinct categories are proposed: HLA-B27 associated and HLA-B27 non-associated reactive arthritis.
  • HLA-B27 associated arthritis may present as Reiter's syndrome with specific extra-articular manifestations (ureteritis, conjunctivitis), unlike the non-associated form.

Conclusions:

  • A unified nomenclature of "reactive arthritis" is proposed for clarity.
  • The distinction between HLA-B27 associated and non-associated forms is clinically significant.
  • HLA-B27 associated reactive arthritis aligns with spondyloarthropathies, presenting distinct clinical features compared to non-associated forms.

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