[Effect of hydroxyurea treatment on free nucleotides in leukemic leukocytes]

An increase was observed in the pool of free nucleotides of leukaemic leucocytes during treatment with hydroxyurea, which was used as a drug inducing remission in chronic myeloid leukaemia and as an agent synchronizing the cell cycle in the so-called synchronization treatment of acute myeloid leukaemia. The increase in the amount of free nucleotides may depend on their increased synthesis and on their less extensive utilization for synthesis of nucleic acids. According to the authors the observed changes in the pool of free nucloetides may possess certain therapeutic implications.